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Sibutramine, formerly sold under the brand name Meridia among others, is an appetite suppressant that has been discontinued in many countries. 

Uses of Sibutramine:

  • Psychiatric conditions such as bulimia nervosa, anorexia nervosa, serious depression or pre-existing mania
  • Patients with a history of or a predisposition to drug or alcohol abuse
  • Hypersensitivity to the drug or any of the inactive ingredients
  • Patients below 18 and above 65 years of age
  • Concomitant treatment with an MAO inhibitor, antidepressant or other centrally active drugs, particularly other anorectics
  • History of peripheral arterial disease
  • Hypertension that is not sufficiently controlled (e.g., >145/90 mmHg), caution in controlled hypertension
  • Existing pulmonary hypertension
  • Existing damage to heart valves, coronary heart disease, congestive heart failure, serious arrhythmias, and previous myocardial infarction
  • A history of coronary artery disease (e.g., angina, history of myocardial infarction), congestive heart failure, tachycardia, peripheral arterial
  • occlusive disease, arrhythmia or cerebrovascular disease (a stroke or transient ischemic attack (TIA)))
  • Stroke or transient ischemic attack (TIA)
  • Hyperthyroidism (overactive thyroid gland)
  • Closed-angle glaucoma
  • Seizure disorders
  • Enlargement of the prostate gland with urinary retention (relative contraindication)
  • Pheochromocytoma
  • Pregnant and lactating women (relative contraindication). online.

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Usual Adult Dose for Obesity:

Sibutramine was voluntarily withdrawn from the US market by the manufacturer in October, 2010 due to clinical trial data indicating an increased risk of heart attack and stroke. The following dosage information applies to when the drug was available in the US.

Initial Dose: 10 mg orally once a day.

Usual Geriatric Dose for Obesity:

Based on one study (n=60)

14 to 17 years:

Initial Dose: 10 mg orally once a day.

What other drugs will affect sibutramine?

Before using sibutramine, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by sibutramine.

Ask your doctor before taking any decongestants, cough medicine, or other diet pills.

The following drugs can interact with sibutramine. Tell your doctor if you are using any of these:

lithium (Lithobid, Eskalith, and others);

tryptophan or L-tryptophan;

ketoconazole (Nizoral);

antibiotics such as erythromycin (E.E.S., Erypdo, Ery-Tab, Erythrocin);

antidepressants such as citalopram (Celexa), desvenlafaxine (Pristiq), duloxetine (Cymbalta), fluoxetine (Prozac, Sarafem, Symbyax), paroxetine (Paxil), sertraline (Zoloft), venlafaxine (Effexor), and others

ergot medicine such as dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), ergotamine (Ergomar), or methylergonovine (Methergine).

migraine headache medicine such as sumatriptan (Imitrex) or zolmitriptan (Zomig); or

narcotic pain medication such as fentanyl (Actiq, Duragesic, Fentora, Onsolis), meperidine (Demerol), pentazocine (Talwin).

The list is incomplete and other drugs may interact with sibutramine. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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